dimerization site of Gads

Targeting Signaling Complexes in Allergy

Gads plays an important regulatory role in allergy; indeed, we showed that Gads dimerization is required for allergic responsiveness in a mouse model. We are developing new biophysical assays with which to characterize Gads dimerization and its cooperative binding to LAT. This research direction may lead to the development of novel strategies for the treatment of allergy.